Standardised nortriptyline and psychotherapy were more effective and more expensive than usual care in major depression

Physician extenders were more cost-effective than usual health care In men with hyperchoBestemlemia

and Commentary also published in ACP Journal Club. 1996; 12 5:80. on the marginal costs and effectiveness of each step along the treatment algorithm were not reported. Therefore, the study is more valuable in relation to the mode of treatment delivery than for details about the treatment itself. Pharoah and HoUingvrorth concentrate on variations in effectiveness and cost among different treatme...

Healthcare assistant case management may reduce depression symptoms in primary care patients with major depression more than usual care.

A plethora of trial results have been published showing that case management improves outcomes in depression.1 2 However, these trials generally involve relatively expensive specialist mental health case managers, plus input from psychiatrists or psychologists.3 Most studies have been conducted in academic or managed care settings, and in the USA. The challenge is to roll out case management in...

A home monitoring service was more effective than usual care in patients with essential hypertension.

P a t i e n t s 121 patients (mean age 62 y, 50% women) with essential hypertension who needed to change their antihypertensive therapy because of elevated blood pressure (BP) despite current use of antihypertensive medication, with undesirable side effects from the current antihypertensive drug, or with an office systolic BP ≥ 180 mm Hg or a diastolic BP ≥ 110 mm Hg with no current use of medi...

Building Ribosomes: Even More Expensive Than Expected?

Recent quantitative analyses of ribosomal protein trafficking in HeLa cells have revealed a prominent and unexpected role for the proteasome in regulating the availability of ribosomal proteins for subunit assembly.

arsenic nanoparticles induced apoptosis more than usual in rat hepatocytes